Nefopam Hydrochloride

Generic Name

• Nefopam Hydrochloride

Drug Class

• Non-opioid analgesic

• Centrally acting pain reliever

Description

Nefopam hydrochloride is a synthetic analgesic that works on the central nervous system (CNS). It relieves pain without being:

• An opioid (like morphine)

• A non-steroidal anti-inflammatory drug (NSAID)

• A steroid

It is chemically related to diphenhydramine-type compounds but does not have strong anti-inflammatory properties.

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Mechanism of Action

Nefopam works by:

• Inhibiting the reuptake of serotonin, norepinephrine, and dopamine

• Modulating pain perception in the brain and spinal cord

It does not cause respiratory depression like opioids.

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Indications (Uses)

Used for:

• Post-operative pain

• Musculoskeletal pain

• Traumatic pain

• Acute moderate pain when opioids are not suitable

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Dosage Form

• Oral tablets (commonly 30 mg per tablet, depending on manufacturer and country)

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Common Side Effects

• Nausea

• Sweating

• Dizziness

• Dry mouth

• Increased heart rate (tachycardia)

• Nervousness

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Serious Adverse Effects (Less Common)

• Hallucinations

• Confusion

• Seizures

• Allergic reactions

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Contraindications

Should not be used in patients with:

• Epilepsy or seizure disorders

• Severe heart disease

• Glaucoma

• Urinary retention

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Pregnancy & Breastfeeding

Use only if clearly prescribed by a healthcare professional. Safety data are limited.

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Storage

• Store below 25C

• Protect from moisture and light

• Keep out of reach of children