Rabeprazole Sodium & Domperidone Capsules

Active Ingredients

1. Rabeprazole Sodium

2. Domperidone

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Drug Class

• Rabeprazole Proton Pump Inhibitor (PPI)

• Domperidone Prokinetic & Antiemetic (dopamine receptor blocker)

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Description

This combination works by:

1 Rabeprazole

• Reduces stomach acid production

• Promotes healing of acid-related damage

2 Domperidone

• Improves stomach movement (gastric emptying)

• Reduces nausea and vomiting

• Prevents reflux of stomach contents

Together, they relieve symptoms of acid reflux and indigestion more effectively than acid suppression alone.

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Indications (Uses)

• Gastroesophageal reflux disease (GERD)

• Acid reflux

• Peptic ulcer disease

• Gastritis

• Functional dyspepsia

• Nausea associated with acid disorders

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Dosage Form

• Capsule (often sustained/controlled release)

• Common strength:

  • Rabeprazole 20 mg

  • Domperidone 1030 mg (varies by brand)

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How It Works

• Rabeprazole blocks the proton pump (H+/K+ ATPase) in stomach lining cells.

• Domperidone blocks dopamine receptors in the gut, improving motility and reducing nausea.

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Common Side Effects

• Headache

• Dry mouth

• Abdominal pain

• Diarrhea or constipation

• Dizziness

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Serious but Rare Side Effects

• Irregular heartbeat (QT prolongation mainly with domperidone)

• Severe allergic reactions

• Long-term PPI use: vitamin B12 deficiency, low magnesium

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Contraindications

Avoid in patients with:

• Severe liver disease

• Known cardiac rhythm disorders

• Gastrointestinal bleeding

• Prolactin-secreting tumors (for domperidone)

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Important Advice

• Usually taken before meals (30 minutes before food)

• Do not crush or chew sustained-release capsules

• Use only as prescribed